From Boston by Car:
Take I-93 South to Route 3 South to the Sagamore Bridge and onto Cape Cod, where it becomes Route 6 East (aka the Mid-Cape Highway).

From New York, Connecticut and Rhode Island by Car:
Take I-95 North to I-195 North to Cape Cod over the Bourne Bridge to Route 6 East.

From Boston by Ferry:
There are two competing services, the Bay State Cruise Co. and Boston Harbor Cruises that cost about the same price ($70 round-trip for the fast ferry). The fast ferry only takes 90 minutes, but the slower ferry (only offered by Bay State Cruises) only costs about $33 round-trip. Once at Provincetown's MacMillan Wharf, you'll catch the shuttle bus or take a taxi to Inn at The Moors

From Boston by Bus:
Plymouth and Brockton buses depart from South Station (Red Line). It's a nice ride but it takes about 3.5 hours and makes a lot of stops; approximate cost is $60 round-trip.

From Boston by Air:
Cape Air (with 12-seater planes) from Logan International Airport costs about $200 round trip and takes about 20 minutes. Taxis from the airport cost about $7 per person.

Getting Around in Provincetown:
It's easy because Provincetown is only three miles long. The summertime shuttle bus only costs $1 and you can flag it down anywhere on Bradford Street or at MacMillian Wharf. It goes right by our door and to Herring Cove Beach. For $7 per person you can take a taxi anywhere in town. Bicycling is also a popular means of transport and rentals are available nearby.